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Research & Publications
2020 - Present
August 2021
Standardizing Definitions of Hematopoietic Recovery, Graft Rejection, Graft Failure, Poor Graft Function, and Donor Chimerism in Allogeneic Hematopoietic Cell Transplantation: A Report on Behalf of the American Society for Transplantation and Cellular Therapy
Kharfan-Dabaja MA, Kumar A, Ayala E, Aljurf M, Nishihori T, Marsh R, Burroughs LM, Majhail N, Al-Homsi AS, Al-Kadhimi ZS, Bar M, Bertaina A, Boelens JJ, Champlin R, Chaudhury S, DeFilipp Z, Dholaria B, El-Jawahri A, Fanning S, Fraint E, Gergis U, Giralt S, Hamilton BK, Hashmi SK, Horn B, Inamoto Y, Jacobsohn DA, Jain T, Johnston L, Kanate AS, Kansagra A, Kassim A, Kean LS, Kitko CL, Knight-Perry J, Kurtzberg J, Liu H, MacMillan ML, Mahmoudjafari Z, Mielcarek M, Mohty M, Nagler A, Nemecek E, Olson TS, Oran B, Perales MA, Prockop SE, Pulsipher MA, Pusic I, Riches ML, Rodriguez C, Romee R, Rondon G, Saad A, Shah N, Shaw PJ, Shenoy S, Sierra J, Talano J, Verneris MR, Veys P, Wagner JE, Savani BN, Hamadani M, Carpenter PA. Transplant Cell Ther. 2021 Aug;27(8):642-649. doi: 10.1016/j.jtct.2021.04.007. PMID: 34304802
November 2021
Blood and Marrow Transplant Clinical Trials Network State of the Science Symposium 2021: Looking Forward as the Network Celebrates its 20th Year
Heslop HE, Stadtmauer EA, Levine JE, Ballen KK, Chen YB, DeZern AE, Eapen M, Hamadani M, Hamilton BK, Hari P, Jones RJ, Logan BR, Kean LS, Leifer ES, Locke FL, Maziarz RT, Nemecek ER, Pasquini M, Phelan R, Riches ML, Shaw BE, Walters MC, Foley A, Devine SM, Horowitz MM. Transplant Cell Ther. 2021 Nov;27(11):885-907. doi: 10.1016/j.jtct.2021.08.016. Epub 2021 Aug 27.PMID: 34461278.
November 9, 2021
Abatacept for GVHD prophylaxis can reduce racial disparities by abrogating the impact of mismatching in unrelated donor stem cell transplantation
Qayed M, Watkins B, Gillespie S, Bratrude B, Betz KM, Choi SW, Davis JH, Duncan C, Giller RH, Grimley M, Harris AC, Jacobsohn DA, Lalefar NR, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Waller EK, Langston A, Kean LS, Horan JT. Blood Adv. 2021 Nov 9:bloodadvances.2021005208. doi: 10.1182/bloodadvances.2021005208. Online ahead of print. PMID: 34753172
January 15, 2021
A Phase 2 Trial of Costimulation Blockade with Abatacept for Prevention of Acute GVHD
Watkins B, Qayed M, McCracken C, Bratrude B, Betz K, Suessmuth Y, Yu A, Sinclair S, Furlan S, Bosinger S, Tkachev V, Rhodes J, Tumlin AG, Narayan A, Cribbin K, Gillespie S, Gooley TA, Pasquini MC, Hebert K, Kapoor U, Rogatko A, Tighiouart M, Kim S, Bresee C, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR2, Yanik GA, Waller EK, Levine JE, Ferrara JL, Blazar BR, Langston A, Horan JT, and Kean LS. 2021 Jan 15. A Phase 2 Trial of Costimulation Blockade with Abatacept for Prevention of Acute GVHD. Journal of Clinical Oncology. In press
August 2021
Multiply restimulated human thymic regulatory T cells express distinct signature regulatory T-cell transcription factors without evidence of exhaustion
Hippen KL, Furlan SN, Roychoudhuri R, Wang E, Zhang Y, Osborn MJ, Merkel SC, Hani S, MacMillan ML, Cichocki F, Miller JS, Wagner JE, Restifo NP, Kean LS, Blazar BR.Cytotherapy. 2021 Aug;23(8):704-714. doi: 10.1016/j.jcyt.2021.02.118. Epub 2021 Apr 20.PMID: 33893050
January 13, 2021
Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states
Tkachev V, Kaminski J, Potter EL, Furlan S, Yu, A, Hunt DJ, McGuckin C, Zheng, H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan J, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS. 2021 Jan 13. Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states. BioRXiv doi: https://doi.org/10.1101/2020.07.20.212399 and Science Translational Medicine. In press
January 13, 2021
Measurement of Leukocyte Trafficking Kinetics in Macaques by Serial Intravascular Staining
Potter EL, Gideon HP, Tkachev V,Fabozzi G, Chassiakos A, Petrovas C, Darrah PA, Lin PL, Foulds KE, Kean LS, Flynn JL, Roederer M. 2021 Jan 13. Measurement of Leukocyte Trafficking Kinetics in Macaques by Serial Intravascular Staining Science. Translational Medicine. In Press
September 24, 2020
Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses
Thangavelu G, Wang C, Loschi M, Saha A, Osborn M, Furlan SN, Aoyama K, McDonald-Hyman C, Aguilar EG, Janesick AS, Chandraratna RA, Refaeli Y, Panoskaltsis-Mortari A, MacDonald KP, Hill GR, Zeiser R, Maillard I, Serody J, Murphy WJ, Munn DH, Blumberg B, Brown C, Kuchroo VK, Kean LS, Hippen K, Noelle RJ, Blazar BR. Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses. Blood 2020 Sep 24:blood.2020005628. doi: 10.1182/blood.2020005628. Online ahead of print. PMID: 32976550
September 30, 2020
Innovations in Primate Interneuron Repertoire
​Krienen FM, Goldman M, Zhang Q, del Rosario R, Florio M, Machold R, Saunders A, Levandowski K, Zaniewski H, Schuman B, Wu C, Lutservitz A, Mullally C, Reed N, Bien E, Bortolin L, Fernandez-Otero M, Lin J, Wysoker A, Nemesh J, Kulp D, Burns M, Tkachev V, Smith R, Walsh CA, Dimidschstein J, Kean LS, Berretta S, Fishell G, Feng G, McCarroll SA. 2020 Sept 30. Innovations in Primate Interneuron Repertoire. Nature. In press
May 28, 2020
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.
Carly G. K. Ziegler, Samuel J. Allon Sarah K. Nyquist, Ian M. Mbano, Vincent N. Miao, Constantine N. Tzouanas, Yuming Cao, Ashraf S. Yousif , Julia Bals , Blake M. Hauser, Jared Feldman, Christoph Muus, Marc H. Wadsworth II, Samuel W. Kazer, Travis K. Hughes, Benjamin Doran, G. James Gatter, Marko Vukovic, Faith Taliaferro, Benjamin E. Mead, Zhiru Guo , Jennifer P. Wang, Delphine Gras, Magali Plaisant , Meshal Ansari , Ilias Angelidis , Heiko Adler , Jennifer M.S. Sucre , Chase J. Taylor , Brian Lin, Avinash Waghray , Vanessa Mitsialis, Daniel F. Dwyer, Kathleen M. Buchheit, Joshua A. Boyce, Nora A. Barrett, Tanya M. Laidlaw, Shaina L. Carroll, Lucrezia Colonna, Victor Tkachev , Christopher W. Peterson , Alison Yu , Hengqi Betty Zheng , Hannah P. Gideon , Caylin G. Winchell, Philana Ling Lin , Colin D. Bingle , Scott B. Snapper , Jonathan A. Kropski , Fabian J. Theis , Herbert B. Schiller , Laure-Emmanuelle Zaragosi , Pascal Barbry Alasdair Leslie, Hans-Peter Kiem , JoAnne L. Flynn , Sarah M. Fortune , Bonnie Berger , Robert W. Finberg , Leslie S. Kean, Manuel Garber, Aaron G. Schmidt, Daniel Lingwood , Alex K. Shalek, Jose Ordovas-Montanes, HCA Lung Biological Network. 2020 SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell.​ 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035.
June 9, 2020
Risk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort.
​Schoettler M, Lehmann LE, Margossian S, Lee M, Kean LS, Kao PC, Ma C, Duncan CN.Risk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort. Blood Advances. 2020 Jun 9;4(11):2536-2547. doi: 10.1182/bloodadvances.2019001242.
July 2, 2020
Robust Expansion of HIV CAR T Cells Following Antigen Boosting in ART-Suppressed Nonhuman Primates.
Rust BJ, Kean LS, Colonna L, Brandenstein K, Poole NH, Obenza W, Enstrom MR, Maldini CR, Ellis GI, Fennessey CM, Huang ML, Keele BF, Jerome K, Riley JL, Kiem HP, Peterson CW. Robust Expansion of HIV CAR T Cells Following Antigen Boosting in ART-Suppressed Nonhuman Primates. Blood. 2020 Jul 2:blood.2020006372. doi: 10.1182/blood.2020006372
July 15, 2020
Isolation of a Highly Purified HSC-enriched CD34+ CD90+ CD45RA- Cell Subset for Allogeneic Transplantation in the Nonhuman Primate Large-animal Model
Radtke S, Colona L, Perez AM, Hoffman M, Kean LS, Kiem H-P (dual-senior author). Allogeneic transplantation of a highly-purified HSC-enriched CD34+CD90+CD45RA– cell subset in the nonhuman primate large-animal model. 2020 Jul 15. Transplantation Direct in press
August, 2020
Single-cell analysis of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn’s Disease
Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A; BCH IBD Center; BWH Crohn’s and Colitis Center, Shalek AK, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper SB, Konnikova L.2020 Single-cell analysis of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn’s Disease. Gastroenterology. 2020 Aug;159(2):591-608.e10. doi: 10.1053/j.gastro.2020.04.074
April 28, 2020
IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer
​Furlan SN , Singh K , Lopez C, Tkachev V , Hunt D, Hibbard J, Betz KM, Blazar BR, Trapnell C, Kean LS. 2020 IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer Blood Advances, 2020 Apr 28;4(8):1594-1605
Cellular Therapeutics and Systems Immunology Lab
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Boston Children's Hospital
Karp Research Building
1 Blackfan Circle
Boston, MA 02115​
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