research & publications
2000 - 2009

October 1, 2009

Resources for genetic management and genomics research on non-human primates at the National Primate Research Centers (NPRCs)

Kanthaswamy S, Capitanio JP, Dubay CJ, Ferguson B, Folks T, Ha JC, Hotchkiss CE, Johnson ZP, Katze MG, Kean LS, Kubisch HM, Lank S, Lyons LA, Miller GM, Nylander J, O'Connor DH, Palermo RE, Smith DG, Vallender EJ, Wiseman RW, Rogers J. Resources for genetic management and genomics research on non-human primates at the National Primate Research Centers (NPRCs). Journal of medical primatology. 2009 Oct 1; 38 Suppl 1: 17-23. PubMed PMID: 19863674.

September 1, 2009

Resource brief: the National Non-Human Primate DNA Bank

Ferguson B, Capitanio J, Folks T, Hotchkiss C, Johnson Z, Kean L, Kubisch HM, Lank S, Lyons L, Miller GM, Nylander J, O'Connor D, Vallender EJ, Wiseman R. Resource brief: the National Non-Human Primate DNA Bank. Methods (San Diego, Calif.). 2009 Sep 1; 49(1): 3-4. PubMed PMID: 19706346; PubMed Central PMCID: PMC3172814.

November 1, 2008

Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.

​Anderson A, Martens CL, Hendrix R, Stempora LL, Miller WP, Hamby K, Russell M, Strobert E, Blazar BR, Pearson TC, Larsen CP, Kean LS. Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2008 Nov 1; 8(11): 2252-64. PubMed PMID: 18801023; PubMed Central PMCID: PMC2874242.

March 1, 2008

Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance

Stapler D, Lee E, Selvaraj SA, Evans AG, Kean LS, Speck SH, Larsen CP, Gangappa S. Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance. Journal of immunology (Baltimore, Md. : 1950). 2008 Mar 1; 180(5): 3190-200. PubMed PMID: 18292543

February 1, 2007

Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression

Kean LS, Adams AB, Strobert E, Hendrix R, Gangappa S, Jones TR, Shirasugi N, Rigby MR, Hamby K, Jiang J, Bello H, Anderson D, Cardona K, Durham MM, Pearson TC, Larsen CP. Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007 Feb 1; 7(2): 320-35. PubMed PMID: 17241112.

July 27, 2007

Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques

 Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation. 2007 Jul 27; 84(2): 196-206. PubMed PMID: 17667811.

August 1, 2007

NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism

Hamby K, Trexler A, Pearson TC, Larsen CP, Rigby MR, Kean LS. NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007 Aug 1; 7(8): 1884-96. PubMed PMID: 17617852.

December 15, 2003

Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease

Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003 Dec 15; 102(13): 4582-93. PubMed PMID: 12933586.

January 1, 2005

Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantation

Roberts C, Kean L, Archer D, Balkan C, Hsu LL. Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantation. Annals of the New York Academy of Sciences. 2005 Jan 1; 1054: 423-8. PubMed PMID: 16339691

March 1, 2002

A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation

Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller EK, Larsen CP, Archer DR. A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood. 2002 Mar 1; 99(5): 1840-9. PubMed PMID: 11861303.

May 1, 2002

Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure

Kean LS, Brown LE, Nichols JW, Mohandas N, Archer DR, Hsu LL. Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure. Experimental hematology. 2002 May 1; 30(5): 394-402. PubMed PMID: 12031645.

July 15, 2001

Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression

Adams AB, Durham MM, Kean L, Shirasugi N, Ha J, Williams MA, Rees PA, Cheung MC, Mittelstaedt S, Bingaman AW, Archer DR, Pearson TC, Waller EK, Larsen CP. Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. Journal of immunology (Baltimore, Md. : 1950). 2001 Jul 15; 167(2): 1103-11. PubMed PMID: 11441122.